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Leadartis announces the publication «An Fc-free EGFR-specific 4-1BB-agonistic trimerbody displays broad anti-tumor activity in humanized murine cancer models without toxicity” in Clinical Cancer Research

https://clincancerres.aacrjournals.org/ Although systemic administration of anti-4-1BB-agonistic IgGs, have shown promise in early clinical studies have not completed clinical development due to their severe hepatotoxicity. Here  we demonstrate that a humanized EGFR-specific 4-1BB-agonistic trimerbody exhibits potent anti-tumor activity […]

Leadartis reaches a major milestone with the demonstration of absence of toxicity of its drug candidate in preclinical models

Leadartis reaches a major milestone with the demonstration of absence of toxicity of its EGFR-targeted 4-1BB-agonistic bispecific Trimerbody which does not Induce Hepatotoxicity in transgenic mice with liver expression of human EGFR (https://www.frontiersin.org/articles/10.3389/fimmu.2020.614363/full). These data support the […]

Telescopes 101

Ut elementum felis a tortor luctus, ut placerat ligula efficitur. Integer tempus odio id augue placerat, vel porttitor mi maximus. Donec egestas ante id orci pretium, eu pellentesque nisi malesuada. Lorem ipsum dolor sit amet, consectetur adipiscing […]

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