Trimerbody^® is a unique mono/multispecific antibody format based on the use of specific collagen trimerization domains and optimized peptide linkers. Trimerbodies are trimeric in solution and exhibit excellent antigen binding capacity and stability in vitro and in vivo.

Leadartis is proud to announce its participation as a partner in the TERET project (New Treatments for Degenerative Retina Diseases) funded by the Spanish Ministry of Economy and Competitiveness (MINECO) under the RETOS of the society program. The MINECO’s participation demonstrates its support of Leadartis technology research and main objectives.

Madrid (September 4th, 2014). Leadartis, a privately held biotechnology company, is pleased to announce the appointment of Dr. Francisco Sanchez-Madrid as a member of its Scientific Advisory Board (SAB). Dr. Sanchez-Madrid together with the outstanding scientists and drug development professionals: Dr. L. Alvarez-Vallina, Dr. P. Kristensen, Dr. I. Melero and Dr. L.

In collaboration with prestigious academic institutions, LeadArtis´scientists demonstrated that single-chain fragment variable (scFv)-based N-terminal Trimerbody® molecules can be efficiently produced in the methylotrophic yeast Pichia pastoris (P. pastoris) in a trimeric fully functional active form. The yield of scFv-based N-terminal Trimerbody® molecules expressed in P. pastoris was about 20-fold higher than in mammalian cells. New marketed therapeutic proteins produced in Pichia evidence the rising interest of P.