Overview

Overview
 
Immuno-oncology is aimed at destroying cancer cells by stimulating the patient's immune system without affecting healthy tissues, with the goal of delivering long-lasting responses and cure. This process is tightly regulated by interactions between receptors on immune cells that influence the immune response against cancer cells. 
 
LeadArtis has generated an array of novel drug candidates, including a tumor-targeted costimulatory MT simultaneously targeting a clinically validated tumor-associated antigen (TAA) on cancer cells and the 4-1BB costimulatory receptor on T cells. A follow-up candidate is a T cell-recruiting bispecific antibody with the ATTACK configuration. 
 
These Trimerbodies allow us to fine tune the potency of the T cell activation and cell killing, potentially improving the tolerability of tumor immunotherapy. We have demonstrated highly effective and well-tolerated killing of target cells in a variety of assays.

Latest News

LeadArtis participates in the fourth Immunostimulatory Agonist Antibodies for Cancer Therapy (IACT) meeting in London (UK)
31-10-2017

The fourth IACT review meeting took place on October 25-26, 2017 in London, United Kingdom....

LeadArtis discloses ATTACK, a novel bispecific T cell-recruiting antibody approach for cancer immunotherapy
15-01-2018

LeadArtis´scientists, in collaboration with other prime...

Leadartis successfully accomplishes the TERET project
07-04-2017

Leadartis is proud to announce the successful conclusion of the TERET (New Treatments for...